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What are the prospects for glass-based microfluidic solutions for exosome isolation?

What would be the advantages of such solutions versus exisint ones? Which companies are working on it?


asked Jul 25, 2013 in ExosomesTalk by notfromtaiwan

1 Answer

In addition to ultracentrifugation several reagents and kits were commercialized over the last 2 years. We have a collection of Total exosome isolation reagents- for all body fluids and cell media. System Biosciences released a proprietary reagent named ExoQuick that can be added to serum, conditioned cell media or urine, and is claimed to precipitate the exosomes. HansaBioMed is offering an array of products called ExoTest kits – featuring anti-CD63, -CD81 or -CD9 antibodies immobilized on 96 well plates – for exosome capturing and characterization. Aethlon Medical released plates with lectins- for exosome capturing. Bioo Scientific launched a kit ExomiR that essentially removes all cells, platelets and cellular debris on one microfilter and captures all vesicles bigger than 30 nm on a second microfilter using positive pressure to drive the fluid. I saw some papers on microfluidic based approaches for exosome isolation (with antibodies eg CD63) but there are no commercially available products like that. Can you tell me more about the glass-based approach?
answered Jul 27, 2013 by Vlassosv